Corel Medical Series: Cancer/Corel Medical Series: Cancer.iso/mac/Program/c23.dxr/00106_Field_SRC.c23.A.21.txt

Text File | 1997-01-28 | 1KB | 17 lines

These include:
• Nearly universal sterility in males and infertility and premature menopause in women over age 25 who receive
  the equivalent of six cycles of MOPP. These effects appear to be largely irreversible. But children born to
  parents treated for Hodgkin's disease by any of the standard treatments have had normal birth weights and no
  increased incidence of birth defects.
• MOPP is also associated with an increased risk—between 1 and 5 percent— of acute leukemia, which is most
  common about four years after treatment and is no longer appreciated by 10 years. The risk of leukemia may
  be increased by the use of MOPP after splenectomy.
• Non-Hodgkin's lymphomas are increased in HD patients treated by any method.
• Patients receiving radiotherapy are at increased risk of developing a second malignancy in the irradiated tissues,
  particularly skin cancer, breast cancer, stomach cancer, soft tissue and bone cancer and lung cancer. Any
  patient who is irradiated would be very wise to stop smoking, since the incidence of lung cancer is strongly
  related to tobacco use.
• There are theoretical concerns with the use of ABVD in that bleomycin may be toxic to the lungs and
  doxorubicin is associated with cardiac toxicity. Both of these effects depend on the dose used and are also
  affected by the combined use of radiotherapy.